Phenotype Image Detail

Image

Caption

Abnormal proliferation and differentiation at the chondro-osseous junction and metaphysis in Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) mice. A, B) BrdU staining shows increase in the numbers of proliferative cells in mutants at E19 (brackets). C-F) In situ hybridization of osteogenic markers shows increased expression in mutants at P0: (C, D) osteopontin; (E, F) bone sialoprotein expression. Panels A, C and E are from littermate controls. Panels B, D and F are the corresponding regions in mutant mice. (Scale bars: A-D = 50 um).

Copyright

This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773

Associated Alleles

Symbol	Name
Fgfr2^tm2Ewj	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2Ewj/Fgfr2^+ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm2Ewj Tg(EIIa-cre)C5379Lmgd