Phenotype Image Detail

Image

Caption

(D-G) Coronal sections of P12 mice injected with Dil in the cochlear nucleus (Hoechst counterstaining). In control (D and E), Dil-labeled axons end in the ipsilateral superior olive (SO) and the contralateral median nucleus of the trapezoid body (MNTB), whereas in Egr2^tm2(cre)Pch/Egr2⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache (Krox20::cre;Robo3^lox/lox) mutant (F and G), all axons project ipsilaterally. The arrow in (D and F) indicates the midline. (E and G) are high magnificationpictures of the MNTB showing Dil-labeled calyces of Held (arrows).

Copyright

This image is from Renier N, PLoS Biol 2010;8(3):e1000325, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158918

Associated Alleles

Symbol	Name
Egr2^tm2(cre)Pch	early growth response 2; targeted mutation 2, Patrick Charnay
Robo3^tm1.1Ache	roundabout guidance receptor 3; targeted mutation 1.1, Alain Chedotal

Associated Genotypes

Allelic Composition	Genetic Background
Egr2^tm2(cre)Pch/Egr2^+ Robo3^tm1.1Ache/Robo3^tm1.1Ache	involves: 129S2/SvPas