Phenotype Image Detail

Image

Caption

Combined Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd Arhgef12^tm1Sgkd/Arhgef12^tm1Sgkd (Prg^-/-/Larg^-/-) embryos are less developed with partial branching failure of the cranial vessels. A, side view of Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd (Prg^-/-/Larg^+/+) and double knock-out Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd Arhgef12^tm1Sgkd/Arhgef12^tm1Sgkd (Prg^-/-/Larg^-/-) E10 embryos. B, whole mount PECAM-1 staining of wild-type (Prg^+/+/Larg^+/+), Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd, and double knock-out E10 embryos. The magnified images show branching of the main cranial vessels of E10 embryos. C, whole mount PECAM-1staining of the trunk of E10 embryos.

Copyright

This image is from Mikelis CM, J Biol Chem 2013 Apr 26;288(17):12232-43 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198274

Associated Alleles

Symbol	Name
Arhgef11^tm1Sgkd	Rho guanine nucleotide exchange factor 11; targeted mutation 1, Silvio Gutkind
Arhgef12^tm1Sgkd	Rho guanine nucleotide exchange factor 12; targeted mutation 1, Silvio Gutkind

Associated Genotypes

Allelic Composition	Genetic Background
Arhgef11^tm1Sgkd/Arhgef11^tm1Sgkd Arhgef12^tm1Sgkd/Arhgef12^tm1Sgkd	involves: 129 * C57BL/6J