Phenotype Image Detail

Image

Caption

Defects in brain and spinal cord in Epg5^tm1Ygz/Epg5^tm1Ygz (Epg5^-/-) mice. (A) Nissl staining of the fifth layer of the cortex in 10-month-old heterozygous and homozygous mutant mice. (B) The number of pyramidal cells in the fifth layer per millimeters squared. (C and D) H&E staining of the hippocampus shows reduced pyramidal cell numbers in homozygous mutant mice. Means +/- SEM of three mice are shown in B and D. (I) Arrows indicate Pyknotic neurons in the anterior horn of mutant mice. (L) Eosinophilic spheroids (arrows) accumulate in the thoracic spinal cord of mutant mice. (M) Eosinophilic spheroids are swollen degenerating axons (arrow). (N) EM pictures showing degenerated axons (arrows) in the spinal cord of mutant mice. Bars: (A, C, and L) 50 um; (I) 100 um; (M) 10 um; (N) 2 um.

Copyright

This image is from Zhao H, J Cell Biol 2013 Mar 18;200(6):731-41, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:196603

Associated Alleles

Symbol	Name
Epg5^tm1Ygz	ectopic P-granules 5 autophagy tethering factor; targeted mutation 1, Yan G Zhao

Associated Genotypes

Allelic Composition	Genetic Background
Epg5^tm1Ygz/Epg5^tm1Ygz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N