Phenotype Image Detail

Image

Caption

Epg5^tm1Ygz/Epg5^tm1Ygz (Epg5^-/-) mice show muscle atrophy. (A and B) Electromyography of the gastrocnemius muscle from a 3-month-old mutant mouse showing fibrillations (A) and positive sharp waves (B). These defects were absent in control mice. (C) At 10 months, mutant mice showed high-amplitude and long-duration action potentials when conducting MUAP tests. The blue lines show the start and end of an action potential. Dur, duration; Amp, amplitude. (D-F) H&E staining of gastrocnemius muscles showed features of muscle degeneration in mutant mice. The arrow in E indicates centrally nucleated fibers.

Copyright

This image is from Zhao H, J Cell Biol 2013 Mar 18;200(6):731-41, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:196603

Associated Alleles

Symbol	Name
Epg5^tm1Ygz	ectopic P-granules 5 autophagy tethering factor; targeted mutation 1, Yan G Zhao

Associated Genotypes

Allelic Composition	Genetic Background
Epg5^tm1Ygz/Epg5^tm1Ygz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N