Phenotype Image Detail

Image

Caption

Mad2l2 (REV7) deficiency increases the number of apoptotic cells among forebrain neuroblasts but does not affect cell proliferation. A, detection of apoptotic cells in the forebrain. Sections of the forebrain of wild-type (Rev7^+/+) and Mad2l2^tm1Ymu/Mad2l2^tm1Ymu (Rev7^-/-) mutant mouse embryos at E11.5 were immunostained with the anti-cleaved caspase-3 antibody. Scale bars, 200 um. B, percentages of cleaved caspase-3-positive cells (mean +/- S.D.) among the forebrain neuroblasts of wild-type and mutant embryos shown in A. An asterisk indicates a significant difference between wild-type and mutant embryos (p<0.05).

Copyright

This image is from Watanabe N, J Biol Chem 2013 Apr 12;288(15):10459-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198275

Associated Alleles

Symbol	Name
Mad2l2^tm1Ymu	MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Yoshiki Murakumo

Associated Genotypes

Allelic Composition	Genetic Background
Mad2l2^tm1Ymu/Mad2l2^tm1Ymu	involves: 129 * C57BL/6J