Phenotype Image Detail

Image

Caption

(C) Upper panel; H&E stained example of whole mouse embryo (E18.5) cross-sections below the level of the tracheal bifurcation showing dilated and enlarged heart in Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺ mice with the maternally inherited allele. (Bar 1 mm). Lower panels; higher power H&E images (Bar 0.25 mm showing regions visualized by immune-fluoresence labeling of IGF2R (green), LAMP1 (red, for endosomal compartment localization) and DAPI (nuclear DNA). Relative IGF2R levels appear reduced including the pericardial regions (Bar 0.1 mm).

Copyright

This image is from Hughes J, PLoS One 2013;8(2):e57270, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:197171

Associated Alleles

Symbol	Name
Igf2r^tm1.1(IGF2R)Arte	insulin-like growth factor 2 receptor; targeted mutation 1.1, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Igf2r^tm1.1(IGF2R)Arte/Igf2r^+	involves: C57BL/6J * C57BL/6NTac