Phenotype Image Detail

Image

Caption

Deletion of Map3k7 (Tak1) in neural crest cells leads to mandibular hypoplasia and cleft palate. 1C, lateral and superior microCT images of control (Tak1^FX/+/Wnt1-Cre^-) and Map3k7^tm1Mis/Map3k7^tm1Mis H2az2^{Tg(Wnt1-cre)11Rth}/0 (Tak1^FX/FX/Wnt1-Cre⁺) heads at P0. The yellow arrows in the lateral images depict the length of the mandible. The yellow arrows in the superior views depict the length of the maxilla. The red arrows in the superior images depict the length of the cranial base, and the green arrows illustrate palatine bones in a control (fused palate) and mutant (cleft palate). The bar graph shows lengths of the cranial base, maxilla, and mandible of controls (blue columns) and mutants (red columns) (n = 3). D-F, histological comparison of palatal phenotypes of controls and mutants: frontal sections at anterior, middle, and posterior levels at E14.5 (E), E18.0 (F), and the level of the first molar at E13.5 (D). The blackarrows point to tips of palatal shelves, the black arrowheads point to the midline seam (in a control), and the black vertical lines depict the distance between the tongue and nasal septum. NS, nasal septum; P, palatal shelf; SP, secondary palate.

Copyright

This image is from Yumoto K, J Biol Chem 2013 May 10;288(19):13467-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198588

Associated Alleles

Symbol	Name
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
Map3k7^tm1Mis	mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Yuji Mishina

Associated Genotypes

Allelic Composition	Genetic Background
Map3k7^tm1Mis/Map3k7^tm1Mis H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * CBA/J