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Caption | Collagen VI deficiency in skeletal muscle and dermal fibroblasts of the Col6a3 mutant mice. A, cryosections of quadriceps muscles from 1-month-old wild-type (+/+), heterozygous (+/-hm) and Col6a3tm1Chu/Col6a3tm1Chu (hm/hm) littermates immunostained with polyclonal antibodies specific for the alpha3(VI) and alpha1(VI) collagens. B, immunostaining of collagen VI deposited by fibroblasts from the wild-type, heterozygous and homozygous mutant littermates. Cells were grown in the presence of 50 ug/ml ascorbate phosphate for 4 days postconfluence and then stained with polyclonal antibodies specific for the alpha3(VI) and alpha1(VI) collagens. Note the intracellular accumulation of the alpha1(VI) collagen in the heterozygous and homozygous fibroblasts. Magnification bars, 50 um. | ||||
Copyright | This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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