Phenotype Image Detail

Image

Caption

Collagen VI deficiency in skeletal muscle and dermal fibroblasts of the Col6a3 mutant mice. A, cryosections of quadriceps muscles from 1-month-old wild-type (+/+), heterozygous (+/-hm) and Col6a3^tm1Chu/Col6a3^tm1Chu (hm/hm) littermates immunostained with polyclonal antibodies specific for the alpha3(VI) and alpha1(VI) collagens. B, immunostaining of collagen VI deposited by fibroblasts from the wild-type, heterozygous and homozygous mutant littermates. Cells were grown in the presence of 50 ug/ml ascorbate phosphate for 4 days postconfluence and then stained with polyclonal antibodies specific for the alpha3(VI) and alpha1(VI) collagens. Note the intracellular accumulation of the alpha1(VI) collagen in the heterozygous and homozygous fibroblasts. Magnification bars, 50 um.

Copyright

This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581

Associated Alleles

Symbol	Name
Col6a3^tm1Chu	collagen, type VI, alpha 3; targeted mutation 1, Mon-Li Chu

Associated Genotypes

Allelic Composition	Genetic Background
Col6a3^tm1Chu/Col6a3^tm1Chu	B6.129-Col6a3^tm1Chu