Phenotype Image Detail

Image

Caption

Abnormal collagen fibril assembly in tendon of the Col6a3^tm1Chu/ Col6a3^tm1Chu (hm/hm) mice. Transmission electron micrographs of tendons from 1 month-old wild-type (+/+) and mutant mice are shown. A, flexor digitorum longus tendons. Low magnification images (panels a and d; scale bar, 1 um) show disorganization of cell and matrix in the mutant tendon (panel d) compared with the wild-type tendon (panel a). At high magnification, collagen fibrils from the wild-type mice (panels b and c) display normal cross-sectional profiles in both central (panel c) and pericellular (panel b) regions. The fibrils are circular with a heterogeneous distribution of fibril diameters. In contrast, the mutant tendons (panels e and f) have larger numbers of smaller diameter fibrils (arrows) in both central (panel f) and pericellular (panel e) areas. Very large, twisted, and structurally abnormal fibrils (arrowheads and curved arrow) are found in the pericellular (panel e), but not central (panel f), areas. Scale bars, 100 nm.

Copyright

This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581

Associated Alleles

Symbol	Name
Col6a3^tm1Chu	collagen, type VI, alpha 3; targeted mutation 1, Mon-Li Chu

Associated Genotypes

Allelic Composition	Genetic Background
Col6a3^tm1Chu/Col6a3^tm1Chu	B6.129-Col6a3^tm1Chu