Phenotype Image Detail

Image

Caption

Histology analysis of kidneys from Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ (Rosa-PEP-R619W/CD19-Cre) mice and control Cd19^tm1(cre)Cgn/Cd19⁺ (CD19-Cre) mice. Three of four mutant mice evaluated exhibited significant renal abnormalities compared with control animals. Scale bars: 50 um.

Copyright

This image is from Dai X, J Clin Invest 2013 May 1;123(5):2024-36 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201448

Associated Alleles

Symbol	Name
Cd19^tm1(cre)Cgn	CD19 antigen; targeted mutation 1, University of Cologne
Gt(ROSA)26Sor^tm1(Ptpn22*)Draw	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Rawlings

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(Ptpn22*)Draw/Gt(ROSA)26Sor^+ Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * C57BL/6