Phenotype Image Detail

Image

Caption

Aged Ptpn22^tm1.1Draw/Ptpn22^tm1.1Draw (PEP-R619W) mice develop modest renal glomerular injury. Representative histopathology studies of kidneys from 10 month old wild-type (WT) and mutant mice showing increased glomerular cellularity and mesangial matrix (right panels, Silver and PAS stains) and glomerular infiltration of Mac-2+ cells [right panel, Mac-2 immunohistochemistry (IHC)]. Scale bars: 50 um. Data shown are representative of findings from 3 WT, 4 heterozygous and 4 homozygous mice.

Copyright

This image is from Dai X, J Clin Invest 2013 May 1;123(5):2024-36 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201448

Associated Alleles

Symbol	Name
Ptpn22^tm1.1Draw	protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1.1, David Rawlings

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn22^tm1.1Draw/Ptpn22^tm1.1Draw	involves: 129 * C57BL/6