Phenotype Image Detail

Image

Caption

Segmented peripheral nervous system (PNS) organization is lost in Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan Tg(T-cre)1Lwd/0 (ROSA^AC/AC;T-Cre) mutants. (A and B) Analysis of PNS organization and spinal nerve projections at the thoracic level by whole-mount staining for neurofilament on E11.5 control and mutant embryos (FL, forelimb). (Insets) Magnified regions. (B) White arrowheads indicate spinal neuron invasion in the entire somite in mutant compared with the neat triangular bundles (black arrowheads) found at the same axial level in control (A).

Copyright

This image is from Lopez TP, Proc Natl Acad Sci U S A 2013 May 28;110(22):E2019-27. Copyright 2013 National Academy of Sciences, U.S.A. J:197427

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1Fan	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chen-Ming Fan
Tg(T-cre)1Lwd	transgene insertion 1, Mark Lewandoski

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1Fan/Gt(ROSA)26Sor^tm1Fan Tg(T-cre)1Lwd/0	involves: C3H * C57BL/6 * C57BL/6J