Phenotype Image Detail

Image

Caption

Lung sections from Edn2^tm1Ywa/Edn2^tm1Ywa (Et2 KO; P1-P21) and adult Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 (Et2^f/f;CAGGCre) (8-week-old) mice and their control littermates were stained with H&E. Lungs of Edn2^tm1Ywa/Edn2^tm1Ywa mice exhibited enlarged air spaces with substantial simplification of lung alveolar structure compared with WT controls. Similiar morphological changes were also observed in adult Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 mice. Original magnification, X10.

Copyright

This image is from Chang I, J Clin Invest 2013 Jun 3;123(6):2643-53 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201436

Associated Alleles

Symbol	Name
Edn2^tm1.1Nat	endothelin 2; targeted mutation 1.1, Jeremy Nathans
Edn2^tm1Ywa	endothelin 2; targeted mutation 1, Masashi Yanagisawa
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Edn2^tm1Ywa/Edn2^tm1Ywa	involves: 129S6/SvEvTac