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Caption | Yap loss of function impairs neonatal heart regeneration. Cardiac fibrosis and scar formation were compared in control Yap1tm1.1Eno/Yap1tm1.1Eno (Yapfl/fl) and Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO) mice. Hearts were subjected to left anterior descending coronary artery (LAD) ligation at P2 and analyzed by Masson's trichrome staining of transverse sections at P28. Shown are the site of ligation (marked with an "X") and the four levels at which cardiac fibrosis was evaluated. Serial sections were cut at 200-um intervals from the site of the ligature toward the apex. Three hearts of each genotype were examined; representative hearts are shown. The boundaries of the infarct zones are demarcated by the V-shaped lines on the right. | ||||||
Copyright | This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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