Phenotype Image Detail

Image

Caption

Compound Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO; Taz cKO) mutants exhibit cardiac abnormalities and defects in proliferation and survival. (A) H&E-stained heart sections from control (Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno) and Yap cKO; Taz cKO mice at P1. (Scale bar: 1 mm). (B) PH3-stained sections of hearts fromcontrol and Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 (Yap cKO; Taz cHET) mice at P1. The green signal and white arrowsindicated PH3-positive staining, and the red signal indicates cTnT immunostaining. (Scale bar: 200 um.) (C) TUNEL stained sections of hearts from control and Yap cKO; Taz cHET mice at P4. The red signal and white arrows indicate TUNEL-positive staining. (Scale bar: 200 um.)

Copyright

This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670

Associated Alleles

Symbol	Name
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider
Wwtr1^tm1.1Eno	WW domain containing transcription regulator 1; targeted mutation 1.1, Eric N Olson
Yap1^tm1.1Eno	yes-associated protein 1; targeted mutation 1.1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Wwtr1^tm1.1Eno/Wwtr1^+ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N
Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N