Phenotype Image Detail

Image

Caption

Increased cardiomyocyte proliferation and improved survival after myocardial infarction (MI) in Tg(Myh6-Yap1*S112A)#Eno/0 mice. (A and B) PH3-stained (A) and Aurora B-stained (B) sections of Tg(Myh6-Yap1*S112A)#Eno/0 (Tg) mouse heart at 7 d post-MI performed at P7. (Scale bars: 100 um) (C) PH3-stained sections of hearts of Tg 7 days post-MI performed at P28. The green signal and white arrows indicate PH3- positive staining, and the red signal shows cTnT immunostaining. (Scale bar: 100 um) (D) TUNEL stained sections of hearts of WT and Tg mice at 7 days post-MI performed at P28. The red signal and white arrows indicate TUNEL-positive staining. (Scale bar: 200 um) (E) Quantification of TUNEL-positive cells (n = 4). Data are mean +/- SD. ** P < 0.005. (F) Smooth muscle alpha-actin stained sections of adult hearts from WT and Tg mice (Scale bar: 200 um.)

Copyright

This image is from Xin M, Proc Natl Acad Sci U S A 2013 Aug 20;110(34):13839-44. Copyright 2013 National Academy of Sciences, U.S.A. J:200670

Associated Alleles

Symbol	Name
Tg(Myh6-Yap1*S112A)#Eno	transgene insertion, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Myh6-Yap1*S112A)#Eno/0	involves: C3H * C57BL/6