Phenotype Image Detail

Image

Caption

Loss of Sestd1 causes a spectrum of posterior defects that phenocopies loss of Dact1. A, Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc (Sestd1-/-) phenocopies Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc (Dact1-/-) in mice. Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc mutants (mut) die before or within 1 day of birth, and at postnatal day 0 they have a short tail (arrow). B, Sestd1-/- mutant neonates lack genital tubercle (gt) and anus (a) (filled arrowhead and empty arrowhead). Some Sestd1-/- mutant neonates also have spina bifida (SB) and curled tails. C, Sestd1-/- mutant neonates have blind-ended colons (cn). D, Sestd1-/- mutant neonates have hydronephrotic horseshoe kidneys (hk) and no bladder (b). Scale bar, 500 um. Other abbreviations: wt, wild-type; mut, Sestd1 mutant; c, cecum; k, kidney; hn, hydronephrosis.

Copyright

This image is from Yang X, J Biol Chem 2013 Jul 12;288(28):20111-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:201925

Associated Alleles

Symbol	Name
Dact1^tm1.1Bnrc	dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1.1, Benjamin N R Cheyette
Sestd1^tm1.1Bnrc	SEC14 and spectrin domains 1; targeted mutation 1.1, Benjamin Cheyette

Associated Genotypes

Allelic Composition	Genetic Background
Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc	involves: 129
Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc	involves: 129S6/SvEvTac * C57BL/6NCr