Phenotype Image Detail

Image

Caption

Nabp2 (Ssb1) deletion causes multiple skeletal defects. (A) Alcian blue and Alizarin red staining of control (Ssb1^+/+, Ssb1^+/-) and Nabp2^tm1.2Kkha/Nabp2^tm1.2Kkha (Ssb1^-/-) E18.5 ribcages. (B) Butterfly rib-spread of control and mutant E18.5 ribcages. (C) Comparison of skull anatomy of control and mutant E18.5 embryos. eo, exoccipital; so, supraoccipital; ip interparietal; pr, parietal; fr, frontal; mx, maxilla; md, mandible; bo, basioccipital; ptg, pterygoid; pmx, premaxilla; ppmx, palatal process maxilla; md, mandible; bo, basioccipital; ptg, pterygoid; pmx, premaxilla; ppmx, palatal process maxilla; ppp, palatal process palatine; p, palatine; tr, tympanic ring. (D) Comparison of control and mutant mandibles (Scale = 1 mm). (E) Forelimb and (F) Hindlimb of E18.5 control and mutant embryos. Sc, scapula; H, humerus; R, radius; U, ulna; F, femur; T, tibia. * designates missing fibula. (G) Quantification of long bone measurements of the forelimb and hindlimb of heterozygous and homozygous mutant E18.5 limbs. Data represent the mean 6 SEM of bone length (n = 3 per condition, ***P,0.001, student's t-test). (H) Whole-autopod (top) and skeletal preparation (bottom) of E18.5 forelimbs (left) and hindlimbs (right) from control and mutant embryos.

Copyright

This image is from Shi W, PLoS Genet 2013 Feb;9(2):e1003298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195140

Associated Alleles

Symbol	Name
Nabp2^tm1.2Kkha	nucleic acid binding protein 2; targeted mutation 1.2, Kum Kum Khanna

Associated Genotypes

Allelic Composition	Genetic Background
Nabp2^tm1.2Kkha/Nabp2^tm1.2Kkha	involves: BALB/cJ * C57BL/6J