Phenotype Image Detail

Image

Caption

Transmission electron micrographs show large open intercellular junctions in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 (EC-iDKO) tumor vessels compared with wild-type (WT) tumor vessels. T, tumor cell; P, platelet. Red arrows indicate open endothelial cell junctions. Percentages of disrupted junctions in WT and EC-iDKO tumor vessels are on right. n = 12 (A); Scale bars: 1.5 um (A).

This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966

Associated
Alleles

Symbol	Name
Epn1^tm1.1Wami	epsin 1; targeted mutation 1.1, Wang Min
Epn2^tm1Ocr	epsin 2; targeted mutation 1, Ottavio Cremona
Tg(Cdh5-cre/ERT2)CIVE23Mlia	transgene insertion CIVE23, M Luisa Iruela-Arispe

Associated
Genotypes

Allelic Composition	Genetic Background
Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129X1/SvJ * C57BL/6J

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