Phenotype Image Detail

Image

Caption

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 (EC-iDKO) and Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0 (EC-DKO) mice. (A and B) Representative wild-type (WT) or EC-iDKO mice bearing Lewis Lung carcinoma (LLC) tumors (A) or Melanoma tumors (B) at 18 days post inoculation of tumor cells. Dotted lines indicate tumors. (C) Representative WT or EC-DKO mice bearing LLC tumors at 18 days post inoculation of tumor cells. (D) Representative mouse brain T2-weighted images for WT and EC-iDKO gliomas, 24 days following GL261 cells injection.Images were acquired with a slice thickness of 0.5 mm and a FOV of 2 x 2 cm², for an approximate in-plane resolution of 80 um. Dashed yellow lines mark tumors. (E) Longitudinally cut colon and rectum regions of WT and EC-iDKO mice challenged with azoxymethane (AOM) and dextran sodium sulphate (DSS). Mice were sacrificed after 18 weeks following treatment.

Copyright

This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966

Associated Alleles

Symbol	Name
Epn1^tm1.1Wami	epsin 1; targeted mutation 1.1, Wang Min
Epn2^tm1Ocr	epsin 2; targeted mutation 1, Ottavio Cremona
Tg(Cdh5-cre)7Mlia	transgene insertion 7, M Luisa Iruela-Arispe
Tg(Cdh5-cre/ERT2)CIVE23Mlia	transgene insertion CIVE23, M Luisa Iruela-Arispe

Associated Genotypes

Allelic Composition	Genetic Background
Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129X1/SvJ * C57BL/6J
Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0	involves: C57BL/6J * FVB/N