Phenotype Image Detail

Image

Caption

Increased tumor vessel permeability in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 (EC-iDKO) mice. (A) Transmission EM micrographs of EC-iDKO tumor vessels showing augmented fenestration (arrowheads in left panel) and enlarged vesiculo-vacuolar organelles (arrowheads in right panel). Areas between two arrows are magnified below. Quantification of fenestration and vesiculo-vacuolar organelles is shown atright. (B) Light microscopy micrographs of semi-thin sections of wild-type (WT) or EC-iDKO tumors showing increased permeability in enlarged tumor vessels, massive leakage of blood cells and necrotic tumor areas in EC-iDKO tumor. Blue dotted line outlinestumor vessels. T: tumor cells, V: vessel, BC: blood cells, RBC: red blood cells. Scale bars: 0.5 um (A), 100 um (B).

Copyright

This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966

Associated Alleles

Symbol	Name
Epn1^tm1.1Wami	epsin 1; targeted mutation 1.1, Wang Min
Epn2^tm1Ocr	epsin 2; targeted mutation 1, Ottavio Cremona
Tg(Cdh5-cre/ERT2)CIVE23Mlia	transgene insertion CIVE23, M Luisa Iruela-Arispe

Associated Genotypes

Allelic Composition	Genetic Background
Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0	involves: 129X1/SvJ * C57BL/6J