Phenotype Image Detail

Image

Caption

(F) Male urogenital systems of Tg(TRAMP)8247Ng/0 (TRAMP-WT) and Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0 (TRAMP-EC-iDKO) mice show prostate tumors. Blue dotted line indicates tumor in prostates. Mice were sacrificed at 36 weeks.

Copyright

This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966

Associated Alleles

Symbol	Name
Epn1^tm1.1Wami	epsin 1; targeted mutation 1.1, Wang Min
Epn2^tm1Ocr	epsin 2; targeted mutation 1, Ottavio Cremona
Tg(Cdh5-cre/ERT2)CIVE23Mlia	transgene insertion CIVE23, M Luisa Iruela-Arispe
Tg(TRAMP)8247Ng	transgene insertion 8247, Norman M Greenberg

Associated Genotypes

Allelic Composition	Genetic Background
Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 Tg(TRAMP)8247Ng/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6J