Phenotype Image Detail

Image

Caption

Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) pups exhibit focal desquamation and abnormal epidermal histology. (A and B), Wild-type (Sgpp1^+/+) and Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) mice at 0.5 days (A) and 4 days after birth (B). The arrows in B indicate sites of desquamation. C-E, histology of mutant mouse skin. Paraffin sections of back skin from 2-day-old wild-type (C) and mutant (D and E) mice were stained with H&E. E represents a region of back skin undergoing peeling of the stratum corneum (marked by arrows) Bar, 200 um. SC, stratum corneum; SL, subcorneal layer.

Copyright

This image is from Allende ML, J Biol Chem 2013 Jun 21;288(25):18381-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199597

Associated Alleles

Symbol	Name
Sgpp1^tm1(KOMP)Vlcg	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1^tm1(KOMP)Vlcg	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Sgpp1^tm1(KOMP)Vlcg/Sgpp1^tm1(KOMP)Vlcg	involves: C57BL/6NTac