Phenotype Image Detail

Image

Caption

Surviving Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) adult mice displayed abnormal skin phenotype. A, surviving adult Sgpp1^-/- (mutant) mouse and its Sgpp1^+/+, (wild-type, WT) littermate. Arrows indicate the deep constriction rings found on the tails of mutant mice. B and C, paraffin sections from WT (B) and mutant (C) adult mouse back skin stained with H&E. Bar, 200 um. SC, stratum corneum; SL, subcorneal layer. D-K, immunohistochemistry of WT and mutant adult mouse skin. Paraffin sections were stained with antibodies against keratin 6 (D and E), keratin 14 (F and G), Ki67 antigen (H and I), filaggrin (J and K) (green staining), and DAPI (blue). The white line represents the edge of the stratum corneum to mark the skin limit on the top of the image. Bar, 100 um.

Copyright

This image is from Allende ML, J Biol Chem 2013 Jun 21;288(25):18381-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199597

Associated Alleles

Symbol	Name
Sgpp1^tm1(KOMP)Vlcg	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1^tm1(KOMP)Vlcg	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Sgpp1^tm1(KOMP)Vlcg/Sgpp1^tm1(KOMP)Vlcg	involves: C57BL/6NTac