Phenotype Image Detail

Image

Caption

Bone resorption is increased in Nlrp3^tm3.1Hhf/Nlrp3⁺ (NOMID) mice. Femoral sections from P13 mice were stained with H&E (A) or for TRAP activity (B). Mutant mice exhibited a larger bone marrow cavity in relation to overall bone size compared to wild-type (WT) mice (A). Abundant osteoclasts (OC) (stained in red, B) were present in the primary spongiosa and on the endocortical bone surface of mutant mice. There were fewer trabeculae (T) and thinner cortical bone (bracket) in mutant compared to WT mice. Original magnification: X2 (A), X10 (B, trabecular region), X20 (B, cortical region).

Copyright

This image is from Bonar SL, PLoS One 2012;7(4):e35979, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:202147

Associated Alleles

Symbol	Name
Nlrp3^tm3.1Hhf	NLR family, pyrin domain containing 3; targeted mutation 3.1, Hal M Hoffman

Associated Genotypes

Allelic Composition	Genetic Background
Nlrp3^tm3.1Hhf/Nlrp3^+	involves: 129