Phenotype Image Detail

Image

Caption

Mesenchymal removal of Smo in the developing intestine. B and C, H&E staining of the intestine of control and Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^tm2Amc/Smo^tm2Amc (Nkx3.2^Cre;Smo^C/C) embryos at E18.5. White dashed lines delineate the boundary of gut epithelium and mesenchyme. D-K, defects in mesenchymal growth and patterning in mutant embryos at E18.5. Shown is immunohistochemical staining of Ki67 (D and H), cleaved caspase 3 (E and I), SMA (F and J), and Beta-tubulin (G and K) in the intestine of control and mutant embryos.

Copyright

This image is from Huang H, J Biol Chem 2013 Jun 14;288(24):17589-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199664

Associated Alleles

Symbol	Name
Nkx3-2^tm1(cre)Wez	NK3 homeobox 2; targeted mutation 1, Warren E Zimmer
Smo^tm2Amc	smoothened, frizzled class receptor; targeted mutation 2, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2^+	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ