Phenotype Image Detail

Image

Caption

Neural-specific deletion of nucleostemin (Gnl3) triggers DNA damage in vivo in Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt Tg(Nes-cre)1Kln/0 (neNS^cko) embryos. (A) At E10.5, the neuroepithelial morphology of mutant embryos appears indistinguishable from that of control Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt (NS^f/f) embryos. (B) Confocal immunofluorescence reveals a significant increase of gamma-H2AX+ cells (red) in the forebrain (B1) and hindbrain (B2) regions of the developing neuroepithelium of mutant embryos at E12.5. (Scale bars: 100 um.)

Copyright

This image is from Meng L, Proc Natl Acad Sci U S A 2013 Jul 9;110(28):11415-20. Copyright 2013 National Academy of Sciences, U.S.A. J:198698

Associated Alleles

Symbol	Name
Gnl3^tm2.1Rylt	guanine nucleotide binding protein nucleolar 3; targeted mutation 2.1, Robert Y L Tsai
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Gnl3^tm2.1Rylt/Gnl3^tm2.1Rylt Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6 * CBA