Phenotype Image Detail

Image

Caption

Crx^Rip/Crx⁺ (Crx^Rip/+) retinas display immature cone-like photoreceptors and long-term preservation of the outer nuclear layer. Methacrylate sections followed by H&E staining of retinas from 5-week-, 10-week-, and 9-month-old wild-type, Crx^Rip/Crx⁺, Crx^Rip/Crx^Rip, and Crx^tm1Clc/Crx^tm1Clc (Crx^-/-) mice. The thickness of the outer nuclear layer in Crx^Rip/Crx⁺ mice is relatively well preserved at 5 weeks and remains largely unchanged at least up to 18 months. The photoreceptor layer in Crx^Rip/Crx^Rip and Crx^tm1Clc/Crx^tm1Clc retinas underwent rapid degeneration between 5 and 10 weeks of age. rpe, retinal pigment epithelium; os, outer segment; is, inner segment; gcl, ganglion cell layer. Scale bar: 40 um.

Copyright

This image is from Roger JE, J Clin Invest 2014 Jan 2;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:203337

Associated Alleles

Symbol	Name
Crx^Rip	cone-rod homeobox; retina with immature photoreceptors
Crx^tm1Clc	cone-rod homeobox; targeted mutation 1, Constance L Cepko

Associated Genotypes

Allelic Composition	Genetic Background
Crx^Rip/Crx^+	C57BL/6J-Crx^Rip
Crx^Rip/Crx^Rip	C57BL/6J-Crx^Rip
Crx^tm1Clc/Crx^tm1Clc	involves: 129S6/SvEvTac * C57BL/6J