Phenotype Image Detail

Image

Caption

(B-C) Retinal defects and exudative vasculopathy in adult Fat1^{Gt(KST249)Byg}/Fat1^{Gt(KST249)Byg} Tg(Myl1-lacZ)1Ibdml/0 (Fat1^LacZ/LacZ) retinas. Mutant eyes have an opaque appearance in contrast to wild-type (WT) eyes (B; yellow arrow). Removal of the cornea reveals absence of opening of the pigmented retina (aniridia), which therefore covers the lens and prevents light from entering the eye. (C) Retinal vasculature visualized using isolectinB4 (GS-IB4) staining of flat-mounted adult retinas from WT and mutant mice. The retina of the mutant displayed zones in which the normal net of secondary and tertiary vessels was replaced by disorganized vasculature, revealing numerous intraretinal microvascular abnormalities, including IB4-binding microaneurysms (orange arrows). Insert: Example of severe retinal detachment (red arrows) observed in mutant eyes, visible even through the lens prior to its removal during dissection. Scale bars: (B, C3) 0.5um; (C1-2) 200 um; (C4-5) 80 um, (C6) 30 um.

Copyright

This image is from Caruso N, PLoS Genet 2013 Jun;9(6):e1003550, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199157

Associated Alleles

Symbol	Name
Fat1^Gt(KST249)Byg	FAT atypical cadherin 1; gene trap KST249, BayGenomics
Tg(Myl1-lacZ)1Ibdml	transgene insertion 1, Developmental Biology Institue of Marseilles-Luminy

Associated Genotypes

Allelic Composition	Genetic Background
Fat1^Gt(KST249)Byg/Fat1^Gt(KST249)Byg Tg(Myl1-lacZ)1Ibdml/0	involves: 129P2/OlaHsd