Phenotype Image Detail

Image

Caption

Selective and asymmetric muscle shape abnormalities in E14.5 Fat1^tm1.2Fhel/Fat1^tm1.2Fhel Tg(Myl1-lacZ)1Ibdml/0 (Fat1^{deltaTM/deltaTM}) embryos. Skeletal muscle groups were visualized in E14.5, wild-type (WT) and mutant embryos, by X-gal staining. (A) Low magnification images showing the entire embryos. The drastically reduced length and density of the cutaneous maximus (CM) muscle is also visible at that stage. (B) High magnification views of hindlimb shank musculatures, showing no obvious shape differences, in particular in the tibialis anterior muscles, at that stage. Muscle name abbreviations: bf: biceps femoris; CM: cutaneous maximus; edl: extensor digitorum longus; pd: peroneus digitorum; pl: peroneuslongus; ta: tibialisanterior. (C) Illustration of asymmetry of muscle shape abnormalities observed in two mutant embryos, by showing their respective left and right sides. All red arrows point to shape abnormalities that are different between the two sides.

Copyright

This image is from Caruso N, PLoS Genet 2013 Jun;9(6):e1003550, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199157

Associated Alleles

Symbol	Name
Fat1^tm1.2Fhel	FAT atypical cadherin 1; targeted mutation 1.2, Francoise Helmbacher
Tg(Myl1-lacZ)1Ibdml	transgene insertion 1, Developmental Biology Institue of Marseilles-Luminy

Associated Genotypes

Allelic Composition	Genetic Background
Fat1^tm1.2Fhel/Fat1^tm1.2Fhel Tg(Myl1-lacZ)1Ibdml/0	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J * SJL