Phenotype Image Detail

Image

Caption

Representative images of metaphase spreads of Exo1^tm3.1Wed/Exo1^tm3.1Wed (Exo1^EK/EK), Exo1^tm2Wed/Exo1^tm2Wed (Exo1^null/null) and wild-type (WT) control littermates. (Magnification: 1,000X.) Note that the Exo1^tm2Wed/Exo1^tm2Wed mice displayed predominantly abnormal spindle structures, with mostly achiasmatic univalent chromosomes. (Inset) Two-fold magnification of the boxed field of Exo1^tm2Wed/Exo1^tm2Wed mice displaying mostly univalent chromosomes (arrows).

Copyright

This image is from Schaetzlein S, Proc Natl Acad Sci U S A 2013 Jul 2;110(27):E2470-9. Copyright 2013 National Academy of Sciences, U.S.A. J:198719

Associated Alleles

Symbol	Name
Exo1^tm2Wed	exonuclease 1; targeted mutation 2, Winfried Edelmann

Associated Genotypes

Allelic Composition	Genetic Background
Exo1^tm2Wed/Exo1^tm2Wed	involves: 129 * C57BL/6