Phenotype Image Detail

Image

Caption

(E) Representative H&E staining of kidney tissues from heterozygous Mmut^tm1Cpv/Mmut⁺ Tg(Alb-Mut)#Cpv/0 (Mut^*/-;TgINS-Alb-Mut) vs. Mmut^tm1Cpv/Mmut^tm1Cpv Tg(Alb-Mut)#Cpv/0 (Mut^-/-;TgINS-Alb-Mut) mice fed a high protein diet for 6 months starting at 2-3 until 8-9 months of age [Left vs. Right; black arrows, granular appearance of the cortex (magnification, 10 X); Inset in Right, vacuolar changes of proximal tubular epithelia (40X)].

Copyright

This image is from Manoli I, Proc Natl Acad Sci U S A 2013 Aug 13;110(33):13552-7. Copyright 2013 National Academy of Sciences, U.S.A. J:200689

Associated Alleles

Symbol	Name
Mmut^tm1Cpv	methylmalonyl-Coenzyme A mutase; targeted mutation 1, Charles P Venditti
Tg(Alb-Mut)#Cpv	transgene insertion, Charles P Venditti

Associated Genotypes

Allelic Composition	Genetic Background
Mmut^tm1Cpv/Mmut^tm1Cpv Tg(Alb-Mut)#Cpv/0	involves: C57BL/6
Mmut^tm1Cpv/Mmut^+	involves: C57BL/6