Phenotype Image Detail

Image

Caption

Analysis of alpha-granule content in Nbeal2^tm1Lex/Nbeal2^tm1Lex (-/-) platelets. (A) Representative transmission electron microscopy images of resting wild-type (+/+) and mutant platelets. Note the lack of alpha-granules in mutant platelets. AG, alpha-granules; DG, delta-granules; M, mitochondria; V, vacuoles. Scale bar: 1 um. (B) Mutant platelet ultrastructure. Scale bar: 0.5 um (left); 0.25 um (right).

Copyright

This image is from Deppermann C, J Clin Invest 2013 Jul 1;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201413

Associated Alleles

Symbol	Name
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Nbeal2^tm1Lex/Nbeal2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J