Phenotype Image Detail

Image

Caption

Paucity of alpha-granules but unaltered ultrastructure in Nbeal2^tm1Lex/Nbeal2^tm1Lex (-/-) megakaryocytes (MKs). (A) Representative transmission electron microscopy images of mature bone marrow MKs. Normally developed demarcation membrane system with alpha-granules in a wild-type (+/+) mouse (top left). Scale bar: 1 um. The demarcation membrane system continues to be seen in mutant MKs (top right) but with a deficiency of alpha granules and a markedly increased number of vacuoles in mutant MKs. Scale bar: 1 um. Note the presence of a leukocyte within the cytoplasm of the mutant MK (bottom left). Scale bar: 3 um. Protrusions from the MK cytoplasm and developing proplatelets could be clearly seen in mutant MKs (bottom right). Scale bar: 1 um. VS, vascular sinus.

Copyright

This image is from Deppermann C, J Clin Invest 2013 Jul 1;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201413

Associated Alleles

Symbol	Name
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Nbeal2^tm1Lex/Nbeal2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J