Phenotype Image Detail

Image

Caption

Impaired dermal repair due to reduced myofibroblast activity in wounds of Nbeal2^tm1Lex/Nbeal2^tm1Lex (-/-) mice and severely diminished mature and pro-TGF-beta in mutant platelets. (A-C) Representative sections of wounds at 7 days after injury. Wounds of mutant mice display (A) reduced development of granulation tissue but similar epithelial wound closure (H&E staining), (B) reduced amounts of collagenous granulation tissue (central darker area in picrosirius red stain), (C) and severely diminished myofibroblast numbers per wound. Scale bar: 500 um.

Copyright

This image is from Deppermann C, J Clin Invest 2013 Jul 1;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201413

Associated Alleles

Symbol	Name
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals
Nbeal2^tm1Lex	neurobeachin-like 2; targeted mutation 1, Lexicon Pharmaceuticals

Associated Genotypes

Allelic Composition	Genetic Background
Nbeal2^tm1Lex/Nbeal2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J