Phenotype Image Detail

Image

Caption

Retinal lesion in Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt mice. (A-F) Fundus image from 6-month (A), 12-month (B, C), 18-month (D), 10-month+light (E) mutant mice and 18-month wild-type mice (F). Arrows indicate retinal lesions. (G, H) Indocyanine green angiography showing retinal (G) and choroidal (H) circulation of an 18-month old mutant mouse. Choroidal neovascularisation was not observed in mutant mice.

Copyright

This image is from Chen M, PLoS One 2013;8(4):e61381, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200877

Associated Alleles

Symbol	Name
Ccl2^tm1Rol	C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
Cx3cr1^tm1Litt	C-X3-C motif chemokine receptor 1; targeted mutation 1, Dan R Littman

Associated Genotypes

Allelic Composition	Genetic Background
Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J