Phenotype Image Detail

Image

Caption

Transmission electron microscopic (TEM) images of mouse eyes. (A) Image from an 18-month wild-type (WT) mouse. (B) Image from an 18-month Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt (DKO) mouse. (C) The average thickness of Bruch membrane in WT and mutant mice. N = 6 (eyes). (D) Vacuolated changes in retinal pigment epithelium (RPE) mitochondria from mutant mice. (E) Vacuolated changes (asterisks) in RPE cells in mutant mice. (F) Photoreceptor inner segment damage (arrow) in mutant mice. (G) Photoreceptor inner segment damage (arrows) and outer segment disorientation (arrowheads) in an area without vacuolated RPE damage. BM, Bruch membrane; CP, choroidal capillaries; RPE, retinal pigment epithelium.

Copyright

This image is from Chen M, PLoS One 2013;8(4):e61381, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200877

Associated Alleles

Symbol	Name
Ccl2^tm1Rol	C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
Cx3cr1^tm1Litt	C-X3-C motif chemokine receptor 1; targeted mutation 1, Dan R Littman

Associated Genotypes

Allelic Composition	Genetic Background
Ccl2^tm1Rol/Ccl2^tm1Rol Cx3cr1^tm1Litt/Cx3cr1^tm1Litt	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J