Phenotype Image Detail

Image

Caption

Reduced sympathetic and parasympathetic innervation of the submandibular gland in Elp1^{tm1c(KOMP)Wtsi}/Elp1^{tm1c(KOMP)Wtsi} H2az2^{Tg(Wnt1-cre)11Rth}/0 (CKO) embryos. (A-G) The number of parasympathetic neurons in the submandibular gland (SMG) of CKO embryos is reduced (D-G) compared with littermate controls (A-C). (H-J) Parasympathetic neuronal cell bodies are heavily innervated by TH+ sympathetic terminals in control embryos, whereas TH+ axons are rare in the mutant SMG (E).(Scale bar: A-F, 50 um; H-J, 10 um.) ***P < 0.001.

Copyright

This image is from George L, Proc Natl Acad Sci U S A 2013 Nov 12;110(46):18698-703. Copyright 2013 National Academy of Sciences, U.S.A. J:202989

Associated Alleles

Symbol	Name
Elp1^tm1c(KOMP)Wtsi	elongator complex protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch

Associated Genotypes

Allelic Composition	Genetic Background
Elp1^tm1c(KOMP)Wtsi/Elp1^tm1c(KOMP)Wtsi H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * C57BL/6N * CBA/J