Phenotype Image Detail

Image

Caption

Dose-dependent reduction of the complexity of the peripheral ER but not of the nuclear envelope in neurons in the primary motor cortex of Reep1^tm1.1Cahb/Reep1^tm1.1Cahb (-/-) mice. (A) Representative transmission electron microscopy (TEM) images of neuronal somata in the primary motor cortex of wild-type and Reep1^tm1.1Cahb/Reep1^tm1.1Cahb mice. The cytoplasm is colored in yellow, thenucleus in blue, and the ER in red. Scale bars: 2 um for whole-cell images and 400 nm for insets.

Copyright

This image is from Beetz C, J Clin Invest 2013 Oct 1;123(10):4273-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:204006

Associated Alleles

Symbol	Name
Reep1^tm1.1Cahb	receptor accessory protein 1; targeted mutation 1.1, Christian Hubner

Associated Genotypes

Allelic Composition	Genetic Background
Reep1^tm1.1Cahb/Reep1^tm1.1Cahb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6