Phenotype Image Detail

Image

Caption

Mir26a-1 enhances proliferation and differentiation of the developing endocrine pancreas. Confocal images of double immunostaining for insulin and Ki67 (A) or Ngn3 and Ki67 (B) in E18.5 (A) or E15.5 (B) pancreas of wild-type (WT) and Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}/? (TG) mice. (Scale bars, 50 um.) (A) Insulin-expressing cells are actively proliferating (arrows). (B) Note the higher percentage of Ngn3+ cells among total cells in TG compared with WT pancreas.

Copyright

This image is from Fu X, Proc Natl Acad Sci U S A 2013 Oct 29;110(44):17892-7. Copyright 2013 National Academy of Sciences, U.S.A. J:201964

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1.1(Mir26a-1)Coh	gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, City of Hope, Beckman Research Institute

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1.1(Mir26a-1)Coh/?	involves: 129 * C57BL/6