Phenotype Image Detail

Image

Caption

Myocardial ultrastructure. Masson's trichrome staining of cardiac muscle in wild-type mice (A) and Ndufs6^{Gt(AR0138)Wtsi}/Ndufs6^{Gt(AR0138)Wtsi} (Ndufs6^gt/gt) mice (B), showing fibrosis in the latter as blue staining (arrow). Ultrastructure of myofibers and the nucleus are normal in left ventricular myocardium of wild-type mice (C) and mutant mice (D), but mitochondria in the latter contain central dense areas (arrows). Compared with wild-type mice (E), higher power reveals that myocardial mitochondria of mutant mice have tightly packed central cristae with diminished matrix space (F). [Scale bars, 0.1 mm (A and B); 1 um (C-F)].

Copyright

This image is from Ke BX, Proc Natl Acad Sci U S A 2012 Apr 17;109(16):6165-70. Copyright 2012 National Academy of Sciences, U.S.A. J:183619

Associated Alleles

Symbol	Name
Ndufs6^Gt(AR0138)Wtsi	NADH:ubiquinone oxidoreductase core subunit S6; gene trap AR0138, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Ndufs6^Gt(AR0138)Wtsi/Ndufs6^Gt(AR0138)Wtsi	involves: 129P2/OlaHsd * C57BL/6