Phenotype Image Detail

Image

Caption

Adult Ngf^tm1.1Blhe/Ngf⁺ mice exhibit dilated cardiomyopathy and fibrosis. (A-C) H&E-stained sections of hearts from 8-month-old wild-type (A), Ngf^tm1.1Blhe/Ngf⁺ (B), and Ngfr^tm1Jae/Ngfr^tm1Jae Ngf^tm1.1Blhe/Ngf⁺ (C) mice. (D-F) Higher magnification images. (G-I) Masson's trichrome analysis of hearts from 8-month-old wild-type (G), Ngf^tm1.1Blhe/Ngf⁺ (H), and Ngfr^tm1Jae/Ngfr^tm1Jae Ngf^tm1.1Blhe/Ngf⁺ (G) mice. Red, myocardium. Black, nuclei. Blue, collagen matrix.

Copyright

This image is from Siao CJ, J Exp Med 2012 Nov 19;209(12):2291-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190893

Associated Alleles

Symbol	Name
Ngfr^tm1Jae	nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Rudolf Jaenisch
Ngf^tm1.1Blhe	nerve growth factor; targeted mutation 1.1, Barbara L Hempstead

Associated Genotypes

Allelic Composition	Genetic Background
Ngf^tm1.1Blhe/Ngf^+	B6.Cg-Ngf^tm1.1Blhe
Ngf^tm1.1Blhe/Ngf^+ Ngfr^tm1Jae/Ngfr^tm1Jae	B6.Cg-Ngf^tm1.1Blhe Ngfr^tm1Jae