Phenotype Image Detail

Image

Caption

A, histology of the femoral condyle shows defects in secondary ossification in a 40-week old Tgfb1^{tm1(Tgfb3)Kul}/Tgfb1^{tm1(Tgfb3)Kul} (LBeta3/LBeta3) mouse. B, representative microcomputed tomography colored images from younger mutant and wild-type mice (14 weeks old) confirm the defects seen in the histology. The intensity of color in the images is indicative of mineral density where the color scale represents the grayscale pixel density. C, osteocalcin staining for osteoblasts. Tibias from the wild-type (+/+) mice show recruitment of osteoblasts to the trabecular bone, whereas the numbers of osteoblasts is decreased on the trabecular bone of the mutant mice. Mice were about 40 weeks old.

Copyright

This image is from Hall BE, J Biol Chem 2013 Nov 1;288(44):32074-92 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:204892

Associated Alleles

Symbol	Name
Tgfb1^tm1(Tgfb3)Kul	transforming growth factor, beta 1; targeted mutation 1, Ashok B Kulkarni

Associated Genotypes

Allelic Composition	Genetic Background
Tgfb1^tm1(Tgfb3)Kul/Tgfb1^tm1(Tgfb3)Kul	involves: 129S1/Sv * 129X1/SvJ * C57BL/6