Phenotype Image Detail

Image

Caption

Placental abnormalities in Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt (p600^-/-) animals. (A) Placental labyrinth defects in mutants. H&E staining images of the labyrinth layer of the p600 knockout and control littermate at E12.5 (the area below the dashed lines) are shown. The labyrinth areas of mutant placenta are thinner than those of wild-type (p600^+/+) littermate as shown by arrows. Scale bars indicate 500 um. (B) High magnification images of the labyrinth layer. Dilated blood vessels (arrows) are observed in mutant placenta. Scale bars indicate 50 um. (C) Immunofluorescence staining of blood vessels in labyrinth areas with anti-laminin antibody. The blood vessels in labyrinth are dilated and sparse in mutant animals at E12.5. Scale bars indicate 100 um.

Copyright

This image is from Nakaya T, PLoS One 2013;8(6):e66269, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:203460

Associated Alleles

Symbol	Name
Ubr4^tm1.1Nkt	ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yoshihiro Nakatani

Associated Genotypes

Allelic Composition	Genetic Background
Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt	involves: 129S6/SvEvTac * C57BL/6 * FVB/N