Phenotype Image Detail

Image

Caption

Embryonic Ubr4 (p600) is required for brain development. H&E stained transverse sections of control Ubr4^tm1.2Nkt/Ubr4⁺ Edil3^{Tg(Sox2-cre)1Amc}/0 (p600^+/-) (left) and Ubr4^tm1.2Nkt/Ubr4^tm1.2Nkt Edil3^{Tg(Sox2-cre)1Amc}/0 (p600 cKO) (right) brain at E13.5. Note that the mutant embryo has considerably smaller brain with markedly small ventricular spaces and cephalic mesenchyme tissues. Abbreviations: LGE, lateral ganglionic eminence; CMT, cephalic mesenchyme tissues; LV, lateral ventricle; 3V, third ventricle; and 4V, fourth ventricle. Scale bars indicate 500 um. (B) Magnified images of the lateral ganglionic eminence area of the control (left) and the homozygous mutant (right) brain, the region indicated by rectangles in (A). Scale bars indicate 100 um.

Copyright

This image is from Nakaya T, PLoS One 2013;8(6):e66269, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:203460

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Ubr4^tm1.2Nkt	ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.2, Yoshihiro Nakatani

Associated Genotypes

Allelic Composition	Genetic Background
Ubr4^tm1.2Nkt/Ubr4^tm1.2Nkt Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL