Phenotype Image Detail

Image

Caption

Inactivation of the ATR-Activation-Domain of Topbp1 results in early embryonic developmental defects in Topbp1^tm1.1Zqw/Topbp1^tm1.1Zqw embryos. (A) Decidua at E11.5 from intercrossing of heterozygous Topbp1^tm1.1Zqw mice. Decidua in (I) was genotype Topbp1^tm1.1Zqw/Topbp1⁺ (ki⁺). Decidua in (II) was empty, thus with unclear genotype. Bar= 1 mm. (B) Cultures of E3.5 blastocysts from heterozygous intercrosses. D1: 1 day after culture, D4: 4 days after culture. Arrows indicate inner cellmass (ICM). Bar = 50 micrometers. Genotypes are indicated on the top of respective images. Ki = knock-in; wt = wild-type.

Copyright

This image is from Zhou ZW, PLoS Genet 2013 Aug;9(8):e1003702, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200981

Associated Alleles

Symbol	Name
Topbp1^tm1.1Zqw	topoisomerase (DNA) II binding protein 1; targeted mutation 1.1, Zhao-Qi Wang

Associated Genotypes

Allelic Composition	Genetic Background
Topbp1^tm1.1Zqw/Topbp1^tm1.1Zqw	involves: 129P2/OlaHsd * 129S4/SvJaeSor