Phenotype Image Detail

Image

Caption

Skeletal defects in Hat1^tm1.1Mrpa/Hat1^tm1.1Mrpa (Hat1-/-) mice. A) Micro CT scans of the heads of neonates with the indicated genotype. Top row shows a dorsal view and bottom row shows a ventral view. Arrows indicate defects in the nasal cavity (top) and jaw structures (bottom). B) Micro CT scans of wild-type (WT) and mutant neonates (as indicated) showing a dorsal view of the entire animal. C) Acian blue and Alizarin red stained WT and mutant neonates. D) WT and mutant embryos (12.5 dpc) were stained with anti-Hat1 antibodies. E) Cross section of the head and neck of 11.5 dpc WT and mutant embryos stained with alpha-Hat1 antibody. 2.5x magnification.

Copyright

This image is from Nagarajan P, PLoS Genet 2013 Jun;9(6):e1003518, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199077

Associated Alleles

Symbol	Name
Hat1^tm1.1Mrpa	histone aminotransferase 1; targeted mutation 1.1, Mark R Parthun

Associated Genotypes

Allelic Composition	Genetic Background
Hat1^tm1.1Mrpa/Hat1^tm1.1Mrpa	involves: C57BL/6J