Phenotype Image Detail

Image

Caption

Neuropathologic processes of Prnp^tm3Lnq/Prnp^tm3Lnq (CJD - Creutzfeldt-Jakob Disease) mice. Sections (5 um thick) from paraffin-embedded hippocampal (A-D) or cerebellar (E and F) areas stained with H&E (A and B) or with PrP antibody 3F4 following proteinase K digestion (C-F). Prnp^tm3Lnq/Prnp^tm3Lnq sections are shown (A,C, and E) with corresponding Prnp^tm2Lnq/Prnp^tm2Lnq (FFI) sections (B, D, and F). Prnp^tm3Lnq/Prnp^tm3Lnq (CJD) mice have prominent spongiform degeneration in the hippocampal CA1 region, specifically in the synapse-rich area of the molecular layer. Prnp^tm2Lnq/Prnp^tm2Lnq (FFI) brains do not. (Scale bars: 0.05 mm).

Copyright

This image is from Jackson WS, Proc Natl Acad Sci U S A 2013 Sep 3;110(36):14759-64. Copyright 2013 National Academy of Sciences, U.S.A. J:200974

Associated Alleles

Symbol	Name
Prnp^tm3Lnq	prion protein; targeted mutation 3, Susan Lindquist

Associated Genotypes

Allelic Composition	Genetic Background
Prnp^tm3Lnq/Prnp^tm3Lnq	involves: 129P2/OlaHsd * C57BL/6N