Phenotype Image Detail

Image

Caption

Activation of cell cycle and death markers. Thalamus (A - C) and striatum (D - F) of paraffin-embedded sections from 18-month-old wild-type (A and D), Prnp^tm3Lnq/Prnp^tm3Lnq (CJD) (B and E), and Prnp^tm2Lnq/Prnp^tm2Lnq (FFI) (C and F) mice, stained with antibodies against EndoG (A-C) and H2A.X (D-F). Arrowheads in B and C mark abnormal protein staining. Arrowheads in E mark abnormally large immunopositive nuclear foci. (Scale bar: 0.05 mm).

Copyright

This image is from Jackson WS, Proc Natl Acad Sci U S A 2013 Sep 3;110(36):14759-64. Copyright 2013 National Academy of Sciences, U.S.A. J:200974

Associated Alleles

Symbol	Name
Prnp^tm2Lnq	prion protein; targeted mutation 2, Susan Lindquist
Prnp^tm3Lnq	prion protein; targeted mutation 3, Susan Lindquist

Associated Genotypes

Allelic Composition	Genetic Background
Prnp^tm2Lnq/Prnp^tm2Lnq	involves: 129P2/OlaHsd * C57BL/6N
Prnp^tm3Lnq/Prnp^tm3Lnq	involves: 129P2/OlaHsd * C57BL/6N